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Prescribing & DEA Roadmap

Missouri Registered Nurse Prescriptive authority

Separate professional authority, state registration and federal DEA steps.

Last researched

Showing findings with official source evidence. Check the conditions for each requirement and confirm your circumstances with the board.

Use the boxes to track your preparation. Checking an item does not verify compliance.

Who may prescribe

  • Registered professional nurses may perform medication-related prescribing/treatment acts “as part of a patient’s care” only when an authorized prescriber–RN relationship is clearly in place and verbal or written orders from, and cosigned by, the authorized prescriber delegating the acts would be needed.

    Applies when: Applies to RN medication-related prescribing/treatment acts “as part of a patient’s care,” and does not establish independent RN prescribing without an authorized prescriber relationship.

    Source evidence
    1. 1. pr.mo.gov ↗
      licensed by a state regulatory board to prescribe medications and treatments” [335.016 (10)(c), RSMo] as part of a patient’s care, an authorized prescriber-registered professional nurse relationship must clearly be in place and verbal or written orders from and cosigned by the authorized prescriber delegating the acts would be needed by registered professional nurses.
  • In Missouri collaborative practice arrangements, delegation of authority to a registered professional nurse to administer, dispense, or prescribe drugs and provide treatment may occur only if the registered professional nurse is an advanced practice registered nurse (APRN).

    Applies when: Applies to delegated drug administration/dispensing/prescribing authority within the Missouri collaborative practice framework; does not establish independent RN prescribing authority.

    Source evidence
    1. 1. revisor.mo.gov ↗
      2. (1) Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is an advanced practice registered nurse as defined in subdivision (2) of section 335.016
    2. 2. revisor.mo.gov ↗
      (1) Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is an advanced practice registered nurse as defined in subdivision (2) of section 335.016
  • Missouri collaborative practice arrangements may delegate to a registered professional nurse the authority to administer or dispense drugs and provide treatment only as long as the delivery of health care services is within the scope of practice of the registered professional nurse and consistent with that nurse’s skill, training, and competence.

    Applies when: Applies to delegated drug/treatment acts within collaborative practice; does not define RN prescribing beyond what is delegated and within scope/competence.

    Source evidence
    1. 1. pr.mo.gov ↗
      Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer or dispense drugs and provide treatment as long as the delivery of such health care services is within the scope of practice of the registered professional nurse and is consistent with that nurse’s skill, training and competence.
  • Collaborative practice arrangements “shall be in the form of written agreements, jointly agreed-upon protocols, or standing orders for the delivery of health care services.”

    Applies when: Applies to collaborative practice arrangements involving a physician and registered professional nurse.

    Source evidence
    1. 1. pr.mo.gov ↗
      Collaborative practice arrangements shall be in the form of written agreements, jointly agreed-upon protocols, or standing orders for the delivery of health
    2. 2. pr.mo.gov ↗
      care services.
  • Registered professional nurses may perform nursing acts including prescribing medications/treatments only “as part of a patient’s care” when an “authorized prescriber–registered professional nurse relationship” is clearly in place, with “verbal or written orders from and cosigned by the authorized prescriber delegating the acts.”

    Applies when: Applies to RN nursing acts that include prescribing medications/treatments via delegated orders; does not establish that an RN independently prescribes without an authorized prescriber relationship.

    Source evidence
    1. 1. pr.mo.gov ↗
      licensed by a state regulatory board to prescribe medications and treatments” [335.016 (10)(c), RSMo] as part of a patient’s care, an authorized prescriber-registered professional nurse relationship must clearly be in place and verbal or written orders from and cosigned by the authorized prescriber delegating the acts would be needed by registered professional nurses.
  • RN authority to perform nursing acts that include prescribing medications/treatments requires an “authorized prescriber–registered professional nurse relationship,” and verbal or written orders must come from and be cosigned by the authorized prescriber delegating the acts.

    Applies when: Applies to RN nursing acts that include prescribing medication/treatment as part of an authorized prescriber–RN relationship; does not establish independent RN prescribing authority.

    Source evidence
    1. 1. pr.mo.gov ↗
      licensed by a state regulatory board to prescribe medications and treatments” [335.016 (10)(c), RSMo] as part of a patient’s care, an authorized prescriber-registered professional nurse relationship must clearly be in place and verbal or written orders from and cosigned by the authorized prescriber delegating the acts would be needed by registered professional nurses.
  • In Missouri collaborative practice arrangements, the registered professional nurse may be delegated the authority to administer, dispense, or prescribe drugs and provide treatment only if the nurse is an advanced practice registered nurse (APRN).

    Applies when: Applies to drug-related authority delegated through the Missouri collaborative practice framework (not independent RN prescribing).

    Source evidence
    1. 1. revisor.mo.gov ↗
      2. (1) Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is an advanced practice registered nurse as defined in subdivision (2) of section 335.016

License and education prerequisites

  • The Missouri Board may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who provides proof of successful completion of an advanced pharmacology course that includes preceptorial experience in the prescription of drugs, medicines and therapeutic devices.

    Applies when: Applies to the board’s controlled substance prescriptive authority certificate issuance to an APRN.

    Source evidence
    1. 1. pr.mo.gov ↗
      ** The board of nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who: (1) Submits proof of successful completion of an advanced pharmacology course that shall include preceptorial experience in the prescription of drugs, medicines and therapeutic devices; and
  • For collaborative practice delegation to allow the nurse to administer, dispense, or prescribe drugs, the registered professional nurse must be an advanced practice registered nurse (APRN).

    Applies when: For delegated drug prescribing within Missouri collaborative practice arrangements.

    Source evidence
    1. 1. revisor.mo.gov ↗
      (1) Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is an advanced practice registered nurse as defined in subdivision (2) of section 335.016

Collaboration and supervision

  • Within Missouri collaborative practice arrangements, the delivery of health care services delegated to a registered professional nurse must be within the scope of practice of the nurse and consistent with the nurse’s skill, training, and competence.

    Applies when: Applies to delegated services under collaborative practice arrangements between a physician and RN; does not itself create independent prescribing authority beyond what is delegated and within competence/scope.

    Source evidence
    1. 1. pr.mo.gov ↗
      Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer or dispense drugs and provide treatment as long as the delivery of such health care services is within the scope of practice of the registered professional nurse and is consistent with that nurse’s skill, training and competence.
  • Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is “an advanced practice registered nurse.”

    Applies when: Applies to delegated drug-related authority through Missouri collaborative practice arrangements; does not establish independent RN prescribing authority.

    Source evidence
    1. 1. revisor.mo.gov ↗
      Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer, dispense or prescribe drugs and provide treatment if the registered professional nurse is an advanced practice registered nurse as defined in subdivision (2) of section 335.016.
  • Missouri collaborative practice arrangements “shall be in writing.”

    Applies when: Applies to collaborative practice arrangements that delegate drug-related authority.

    Source evidence
    1. 1. pr.mo.gov ↗
      Collaborative practice arrangements, which shall be in writing, may delegate to a registered professional nurse the authority to administer or dispense drugs and provide treatment as long as the delivery of such health care services is within the scope of practice of the registered professional nurse and is consistent with that nurse’s skill, training and competence.

State controlled-substance authority

  • There is no renewal or expiration date assigned to Controlled Substance Prescriptive Authority eligibility issued by the Board of Nursing; however, this privilege may be removed as a result of disciplinary action or lapse of the RN and/or APRN license.

    Applies when: Applies to Controlled Substance Prescriptive Authority eligibility issued by the Missouri Board of Nursing; it does not state an individual’s personal renewal/expiration date.

    Source evidence
    1. 1. pr.mo.gov ↗
      There is no renewal or expiration date assigned to Controlled Substance Prescriptive Authority eligibility issued by the Board of Nursing.
    2. 2. pr.mo.gov ↗
      However, this privilege may be removed as a result of disciplinary action, lapse of the RN and/or APRN license or the
  • The Missouri Board of Nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who meets specified pharmacology/preceptorial requirements.

    Applies when: Applies to board-issued controlled substance prescriptive authority certificate for an APRN.

    Source evidence
    1. 1. pr.mo.gov ↗
      ** The board of nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who: (1) Submits proof of successful completion of an advanced pharmacology course that shall include preceptorial experience in the prescription of drugs, medicines and therapeutic devices; and
  • There is “no renewal or expiration date assigned to Controlled Substance Prescriptive Authority eligibility issued by the Board….” However, the privilege may be removed as a result of disciplinary action or lapse of the RN and/or APRN license.

    Applies when: Applies to Controlled Substance Prescriptive Authority eligibility issued by the Board; does not state how/when an individual date will occur for a specific holder.

    Source evidence
    1. 1. pr.mo.gov ↗
      There is no renewal or expiration date assigned to Controlled Substance Prescriptive Authority eligibility issued by the Board of Nursing.
    2. 2. pr.mo.gov ↗
      However, this privilege may be removed as a result of disciplinary action, lapse of the RN and/or APRN license or the
  • Missouri’s board of nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse (APRN).

    Applies when: State controlled-substance prescriptive authority certificate under Missouri board of nursing processes (APRN-focused).

    Source evidence
    1. 1. pr.mo.gov ↗
      ** The board of nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who: (1) Submits proof of successful completion of an advanced pharmacology course that shall include preceptorial experience in the prescription of drugs, medicines and therapeutic devices; and

Training and monitoring

  • The controlled substance prescriptive authority instructions require evidence of successful completion of an advanced pharmacology course that includes preceptorial experience, and the application packet requires proof tied to those prerequisites.

    Applies when: Applies to Missouri “Controlled Substance Prescriptive Authority” authorization for APRNs.

    Source evidence
    1. 1. pr.mo.gov ↗
      ** The board of nursing may grant a certificate of controlled substance prescriptive authority to an advanced practice registered nurse who: (1) Submits proof of successful completion of an advanced pharmacology course that shall include preceptorial experience in the prescription of drugs, medicines and therapeutic devices; and
    2. 2. pr.mo.gov ↗
      ** **Submit ONE (1)** of the following to meet the requirements for advanced pharmacology: + Official final transcript that includes an advanced pharmacology course if not already on file with the Board, or + Letter from an advanced practice nursing program describing how

Applications and documents

  • The instructions state you must complete and submit the application for controlled substance prescriptive authority and provide required supporting documents such as the advanced pharmacology evidence and statements for prescriptive delegation and APRN-category practice hours.

    Applies when: Applies to APRN applicants for Missouri Controlled Substance Prescriptive Authority authorization.

    Source evidence
    1. 1. pr.mo.gov ↗
      ** **Complete and submit** the application for controlled substance prescriptive authority **2.
    2. 2. pr.mo.gov ↗
      ** **Submit ONE (1)** of the following to meet the requirements for advanced pharmacology: + Official final transcript that includes an advanced pharmacology course if not already on file with the Board, or + Letter from an advanced practice nursing program describing how
    3. 3. pr.mo.gov ↗
      **5.** **Submit** a completed "Statement of Controlled Substance Delegation”, form provided by the Board.
    4. 4. pr.mo.gov ↗
      **4.** **Submit** a completed "Statement of Practice in APRN category” (on bottom of Statement of Preceptorial Experience page) for evidence of 1000 hours of clinical experience in the advanced practice nursing category.
  • The instructions state that once the Board has received and approved the listed documents, you will then be ready to register with the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the Federal Drug Enforcement Agency (DEA).

    Applies when: Applies after Board approval for controlled substance prescriptive authority authorization; it does not provide DEA renewal timing or DEA fee amounts.

    Source evidence
    1. 1. pr.mo.gov ↗
      Once the Board has received and approved the documents listed above, you will then be ready to register with the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the Federal Drug Enforcement Agency (DEA).
  • Missouri Board instructions state: “There is no renewal or expiration date assigned” to Controlled Substance Prescriptive Authority eligibility issued by the Board of Nursing.

    Applies when: For Controlled Substance Prescriptive Authority eligibility issued by the Board.

    Source evidence
    1. 1. pr.mo.gov ↗
      There is no renewal or expiration date assigned to Controlled Substance Prescriptive Authority eligibility issued by the Board of Nursing.

Authorities and sources

  • Missouri Board of Nursing controlled substance prescriptive authority eligibility describes applying with the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the Federal Drug Enforcement Agency (DEA) for authority to prescribe controlled substances from Schedules II–V as delegated in a collaborative practice arrangement.

    Applies when: Applies to APRNs seeking controlled substance prescriptive authority following board eligibility; does not establish RN prescribing independent of APRN/controlled-substance authorization.

    Source evidence
    1. 1. sos.mo.gov ↗
      authority—Eligibility granted by the MSBN to an APRN to apply with the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the federal Drug Enforcement Agency (DEA) for authority to prescribe controlled substances from Schedules II–V as delegated in a collaborative practice arrangement pursuant to 334.104, RSMo, between a collaborating physician and a collaborating APRN.
  • The controlled substance prescriptive authority instructions identify BNDD and DEA and state readiness to register with both after Board approval.

    Applies when: Applies to the controlled substance prescriptive authority authorization process in Missouri.

    Source evidence
    1. 1. pr.mo.gov ↗
      Once the Board has received and approved the documents listed above, you will then be ready to register with the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the Federal Drug Enforcement Agency (DEA).
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